BK Virus Nephropathy: Prevalence, Impact and Management Strategies
INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE(2020)
Abstract
BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.
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Key words
BK polyomavirus nephropathy,kidney transplant,immune monitoring,treatment,surveillance
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