Greener" Synthesis Of Zoledronic Acid From Imidazol-1-Yl-Acetic Acid And P-Reagents Using Diethyl Carbonate As The Solvent Component
LETTERS IN ORGANIC CHEMISTRY（2021）
Abstract
The synthesis of a third generation dronic acid, zoledronic acid by the reaction of imidazol-1-yl-acetic acid with phosphorus trichloride/phosphorous acid in diethyl carbonate (DEC) as a "green" solvent, and in DEC - methanesulfonic acid (MSA) solvent mixtures is described. The earlier not "green" and expensive MSA and sulfolane solvents may be replaced by DEC.
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Key words
Zoledronic acid, imidazol-1-yl-acetic acid, P-reagents, diethyl carbonate, methanesulfonic acid, sulfolane
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