Right and Left Colon Cancer: Clinico-Pathological Features and Treatment Results (South Egypt Cancer Institute Experience)

Background: Colon cancer (CC) ranks as the third most common cancer worldwide and is\r\nconsidered the second leading cause of cancer death. Recently, many\r\ninternational studies have made the observation that right and left colon\r\ncancer have many significant differences regarding clinico-pathological characteristics and primary tumor location has a crucial impact on\r\ntreatment outcomes and overall survival. Our study was conducted to verify the\r\npresence of significant differences between right and left colon cancer. Patients\r\nand Methods: This study is a retrospective cohort study which aimed at\r\ncomparing right and left colon cancer as regards clinico-pathological data and\r\ntreatment results among patients with colon cancer receiving treatment at South\r\nEgypt Cancer Institute (SECI) during the period from 1/2008 to 12/2018. A\r\nsample size of 160 cases of colon cancer patients (80 diagnosed as right colon\r\ncancer and 80 diagnosed as left colon cancer) was randomly selected from our\r\nSouth Egypt Cancer Institute (SECI)’s tumor registry. Statistical analysis was\r\ndone using SPSS program version 20. Difference was considered statistically\r\nsignificant at P-value Results: Right colon cancer occurred at an older age and was more commonly presented\r\nwith abdominal pain while left colon cancer was more commonly presented with\r\nbleeding manifestations. More cases of the right side underwent curative\r\nsurgeries whereas more palliative surgeries were performed to left-sided cases.\r\nLeft sided cases were associated with a more advanced stage at diagnosis while\r\nright-sided cases were associated with a better response to first-line\r\nchemotherapy. More cases of the left side died due to metastatic disease. On\r\nthe other hand, our findings demonstrated no differences between both sides\r\nregarding gender predilection, risk factors, sites of metastases, number of\r\nmetastatic organs, histo-pathological examination and grading, response to\r\nsecond- or third-line chemotherapy, chemotherapy toxicity (hematological or\r\nnon-hematological), overall survival, progression-free survival, or\r\ndisease-free survival. Conclusion: Primary tumor location of colon\r\ncancer has a significant effect on clinico-pathological characteristics and\r\ntreatment outcomes.