Synthesis And Characterization Of A Symmetrically Substituted Cyclodiphosph(V)Azane Ligand (H4l') And Its Transition Metal Complexes For Antimicrobial And Antitumor Investigation.
EGYPTIAN JOURNAL OF CHEMISTRY(2020)
摘要
A NEW ligand of geminal cyclodiphosph(V)azane derivatives, 1,3-di-[N/-2,6-dimethoxyLl-pyrimidnylsulfanilamide12,4-di-IN/-2-quinoxalinylsulfanilamidel-2,4dichloroc- yelodiphosph(V)azane (H4L') was prepared. The ligand and its related complexes were characterized by different physicochemical techniques, namely; IR, UV vis, mass, 'H NMR, molar conductance, magnetic, solid reflectance, and thermal analysis The spectral data revealed that the ligand behaves as ionic in nature and coordinated to the metal ions via enolic-OH of sulphonamide group and pyrimidine N. The molar conductance data reveal that the complexes were electrolytes, while UV vis, solid reflectance and magnetic moment data have been shown that the complexes have octahedral geometry. The thermal behavior of the complexes was also studied. The ligand and its metal complexes showed a high to moderate antimicrobial activities against deferent strains of bacteria and fungi, also showed anticancer activity against colon carcinoma HCT116.
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关键词
Physicochemical techniques, cyclodiphosph(V)azane ligaud, metal complexes, antimicrobial, anticancer activities
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