The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity

Ivan А. Novakov,Leila L. Brunilina,Ivan А. Kirillov,Maxim B. Nawrozkij,Mariya D. Robinovich, Evgeniya S. Titova,Dmitry S. Sheikin,Evsey А. Ruchko,Alla V. Pavlova,Anastasiya А. Kotlyarova,Tatyana G. Tolstikova

CHEMISTRY OF HETEROCYCLIC COMPOUNDS（2020）

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摘要

New structural analogs of 3-phenacyluridine were obtained as a result of N (3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl) uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.

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3-phenacyluridine,alkylation,biological activity,hypnotics,uridine receptor

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