Mesenchymal Stem Cell (MSC) Derived Exosomes alleviate Pulmonary Hypertension in an Experimental Model of Bronchopulmonary Dysplasia (BPD) Through the Vascular Endothelial Growth Factor Signaling Pathway.

Title: Mesenchymal Stem Cell (MSC) Derived Exosomes Attenuate Pulmonary Hypertension (PH) in an Experimental Model of Bronchopulmonary Dysplasia (BPD) through the Vascular Endothelial Growth Factor Signaling Pathway. Background: Pulmonary Hypertension (PH) is a significant cause of morbidity and mortality in preterm infants with severe bronchopulmonary dysplasia (BPD). Exosomes are nano-sized vesicles that play a key role in intercellular and inter-organ communications. Here, we test the hypothesis that intra-tracheal administration of exosomes derived from Wharton’s jelly (WJ) or bone marrow (BM) MSCs would attenuate PH and vascular remodeling in an experimental model of severe …