Machaerium acutifolium lectin inhibits inflammatory responses through cytokine modulation

Ana L.E. Santos, Cícero P.S. Júnior, Roberval N.M. Neto,Maria. H.C. Santos,Valdenice F. Santos,Bruno A.M. Rocha,Eduardo M. Sousa,Rafael C. Carvalho,Irwin R.A. Menezes,Maria R.C. Oliveira,Lindaiane B.R. Dantas, Tarcísio M. Silva,Claudener S. Teixeira

Process Biochemistry（2020）

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摘要

•MaL inhibited cell migration in experimental models of carrageenan-induced peritonitis.•MaL inhibited formation of paw edema.•MaL caused downregulation of iNOS and TNF-α genes.•MaL caused upregulation of the anti-inflammatory IL-10 gene.

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关键词

Agglutinin,Inflammation,LPS-stimulated macrophages

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