Frontal Fibrosing Alopecia: A Descriptive Cross-Sectional Study Of 711 Cases In Female Patients From The Uk

S.M. McSweeney,E.A.A. Christou,N. Dand, A. Boalch,S. Holmes,M. Harries, I. Palamaras, F. Cunningham, G. Parkins, M. Kaur, P. Farrant,A. McDonagh,A. Messenger,J. Jones, V. Jolliffe, I. Ali,M. Ardern‐Jones,C. Mitchell, N. Burrows, R. Atkar, C. Banfield, A. Alexandroff, C. Champagne, H.L. Cooper, G.K. Patel,A. Macbeth, M. Page, A. Bryden, M. Mowbray, S. Wahie, K. Armstrong, N. Cooke, M. Goodfield, I. Man, D. de Berker, G. Dunnil, A. Takwale, A. Rao, T.‐W. Siah,R. Sinclair, M.S. Wade,K. Bhargava, D.A. Fenton,J.A. McGrath,C. Tziotzios

BRITISH JOURNAL OF DERMATOLOGY(2020)

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摘要
Frontal fibrosing alopecia (FFA) is an inflammatory primary scarring alopecia of uncertain aetiology that represents a variant of lichen planopilaris. It predominantly, although not exclusively, affects post-menopausal women. Its pathogenesis is characterised by immune-mediated follicular destruction at the level of the hair bulge, which leads to a clinical phenotype of progressive fronto-temporal hair and eyebrow loss that is often preceded by widespread body hair loss.
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