Hydrogels based on polysaccharide-calcium phosphate with antibacterial/antitumor activity for 3D printing

The purpose of this study was to develop hydrogels for 3D printing of sodium alginate /gelatin /octacalcium phosphate-based constructs with antibacterial and antitumor activity intended for bone defects replacement in patients with malignant diseases. In this work, we evaluated the drug release kinetic and physico-chemical characteristics of constructs, as well as their specific activity, biocompatibility and osteoplastic properties by means of in vitro and in vivo tests. The principal possibility of creating the biocompatible bone substitutes with antibacterial /antitumor activity and osteoconductive-retaining properties of 3D printing method was demonstrated.