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Process Development of Halaven®: Synthesis of the C14-C35 Fragment Via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization

Brian C. Austad,Farid Benayoud,Trevor L. Calkins,Silvio Campagna,Charles E. Chase,Hyeong-Wook Choi,William Christ,Robert Costanzo,James Cutter,Atsushi Endo,Francis G. Fang,Yongbo Hu,Bryan M. Lewis,Michael D. Lewis,Shawn McKenna,Thomas A. Noland,John D. Orr,Marc Pesant,Matthew J. Schnaderbeck,Gordon D. Wilkie,Taichi Abe,Naoki Asai,Yumi Asai,Akio Kayano,Yuichi Kimoto,Yuki Komatsu,Manabu Kubota,Hirofumi Kuroda,Masanori Mizuno,Taiju Nakamura,Takao Omae,Naoki Ozeki,Taeko Suzuki,Teiji Takigawa,Tomohiro Watanabe,Kazuhiro Yoshizawab

Synlett（2013）

Cited 56|Views12
Key words
antitumor agents,chromium,cyclization,nickel,stereoselective synthesis
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