Experimental modeling of local laser hyperthermia using thermosensitive nanoparticles absorbing in NIR

In this work we investigated the use of composite crystalline core/shell nanoparticles LaF3:Nd3+(1%)@DyPO4 for fluorescence-based contactless thermometry, as well as laser-induced hyperthermia effect in optical model of biological tissue with modeled neoplasm. In preparation for this, a thermal calibration of the nanoparticles luminescence spectra was carried out. The results of the spectroscopic temperature measurement were compared to infrared thermal camera measurements. It showed that there is a significant difference between temperature recorded with IR camera and the actual temperature of the nanoparticles in the depth of the tissue model. The temperature calculated using the spectral method was up to 10 degrees C higher.