Typical Lung Carcinoids with Metastasis: Potential Role of MicroRNAs in the Regulation of Adaptive Immunity Associated with Disease: a Case Study.

Ana L Seneda,Rainer M Lopez Lapa,Tainara F Felix,Iael W Minutentag, Carolina F Campos,Rogério A de Oliveira,Cristiano C Oliveira,Érica N Hasimoto,Daniele C Cataneo,Antonio J M Cataneo,Julio De Faveri,Sandra A Drigo,Luis A J Mur,Patricia P Reis

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

Our results contribute to the identification of miRNA expression changes in a typical lung carcinoid and its corresponding lymph node metastasis. Down-regulated levels of miR-126-3p and miR-146b-5p and target gene over-expression could play a role in the progression of this case of primary typical lung carcinoid to regional metastasis. Identified miRNAs and target genes are potential candidates for validation in a larger number of cases.

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关键词

Lung carcinoid, MicroRNAs, Immune system, Disease progression, Metastasis

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