POSSIBILITIES OF PREDICTION OF NEUROTIC, STRESS-RELATED DISORDERS COURSE IN TERMS OF HORMONAL PARAMETERS

One of the most common and universal disorders of mental adaptation are non-psychotic mental disorders, in which development a large role plays various endocrine and biochemical mechanisms of response to stress. The purpose of the study is to determine the contribution of the endocrine system to the formation of neurotic, stress-related disorders in order to identify the criteria for predicting their protracted course. Material and Methods. A comprehensive clinical-psychopathological and hormonal examination of 43 women (mean age 39.43 +/- 7.23 years) inpatient at the first clinical psychiatric unit of the clinic of Mental Health Research Institute of Tomsk NRMC with various types of the course of neurotic, stress-related disorders was performed. According to the criteria ICD-10 all patients were divided to clinical groups: adjustment disorders (F 43.2) and enduring personality change after psychiatric illness (F 62.1). Investigation of hormonal status included determination of concentrations of cortisol, prolactin and thyroid-stimulating hormone (TSH) in serum by the method Enzyme Immunoassay (EIA). The hormonal status of 32 healthy women was taken as a control. Results. A psychopathological investigation of patients showed that overexertion of protective mental mechanisms associated with the impact of a stressful situation can lead to a breakdown in adaptation, disturbances of normal functioning and the emergence of various neurotic symptoms that fall into the diagnostic category F 43.2 (adjustment disorders). As the damaging effects of unfavorable factors and stressful co-existence accumulated, the "health resources" decreased, which was a starting point in the formation of persistent personality changes and transition to another diagnostic category F 62.1 Persistent personality change after a mental disorder. The characteristics of the hormonal status of patients with a protracted neurotic, stress-related disorders were: high concentrations of cortisol, prolactin and low serum levels of thyrotropic hormone, which allows considering them as predictors of persistent personality change at early stage of the diseases. Conclusion We determined the hormonal criteria for predicting a protracted course of neurotic, stress-related disorders with the formation of a persistent personality changes at an early stage of the disease- at the stage of disorder of adaptive reactions.