Options for Managing Treatment-Resistant Depression

Depression affects 16 million Americans each year, with half of patients experiencing inadequate response to monotherapy with antidepressants. Up to 20% of people may suffer from chronic depression despite treatment. Treatment-resistant depression (TRD) can negatively impact an individual's activities of daily living. Pharmacologic approaches for the management of TRD include optimizing current treatment with correct dosage and agent selection, switching therapy, and augmentation.