Quantitative Analysis of Dysregulated Proteome in Methylmalonic Acidemia

Costanzo Michele,Caterino Marianna,Minopoli Giuseppina,Santorelli Lucia,P. Venditti Charles,Ruoppolo Margherita

NATO Science for Peace and Security Series A-Chemistry and Biology（2017）

引用 0|浏览1

暂无评分

摘要

Methylmalonic Acidemias (MMNAs) are heterogenoeus severe autosomal recessive inborn errors of metabolism, MMNAs are caused by deficency of vitamin B12-dependent methylmalonyl-CoA mutase enzyme (MUT). Therefore, we used MUT silencing and a proteomic quantitative approach to define the pathways directly perturbed by this metabolic disease.

查看译文

关键词

Methylmalonic Acidemia, Quantitative Proteomic Approach, Normalized Spectral Abundance Factor (NSAF), Methylmalonic Acid, Hepatic Proteome

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要