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Obtention of enalapril diketopiperacine as reference substance

Tania Marquez Conde, Ilsa Corrales Alvarez,Manuel Gil Apan, Luis Martinez Alvarez

LATIN AMERICAN JOURNAL OF PHARMACY（2007）

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Abstract
Obtention-of Enalapril Diketopiperacine as Reference Substance. Degradation of enalapril maleate with yield of enalapril diketopiperacine (DKP) was studied to be used as reference substance, including homogeneity and stability studies. Product purity was 99.9% and was homogeneous and stable. Storage is recommended at 20 degrees C and twelve months as revaluation date is suggested.
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Key words
degradation products,enalapril diketopiperacine,homogeneity,reference substance,stability
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