Two novel Fe(II) and Zn(II) Metal Complexes: Inhibiting Growth of Human Lung Cancer Cells

In this work, a pair of C3-symmetric organic ligands, 4,4',4 "-nitrilotrisbenzoic acid (H3NTB) and 4,4', 4 "-(benzene-1,3,5-triyl-tris(oxy)) tribenzoic acid (H3BTTB), were used to target two new metal-organic frameworks [Fe(NTB)(NMF)](NMF) 2 (1, NMF = N-Methylformamide) and [Zn-3(BTTB) 2(H2O)(2)].(DMF)(2) (2, DMF = N, N-dimethylformamide) with diverse architectures via a one pot of solvothermal synthesis. Both of the two complexes are characterized by single-crystal X-ray diffraction and elemental analysis. In addition, in vitro anticancer activities of compounds 1 and 2 on four human lung cancer cell lines (H1299, MSTO-211H, PC9 and A549) was further determined.