Neuropharmacological Activity of Ethanolic Extract from the Leaves of Pericampylus glaucus in Experimental Animals

Present research was designed to evaluate the neuropharmacological activity of ethanol extract of Pericampylus glaucus in experimental animals. The sedative and anxiolytic activity were assessed by open field, cage crossing and head dipping test at dosage rate of 400, 600, and 800 mg/kg (b.wt.), orally. Furthermore, rotarod and force swimming test were employed for muscle relaxant and antidepressant activity. Diazepam was used as a standard in whole studies that was injected intraperitonealy at dose rate of 5 mg/kg (b.wt.). A non significant (p > 0.05) in square crossing were noted with ethanol extract of P. glaucus at dose rate of 400 mg/kg (b.wt.) that decreased significantly (p < 0.01) with ethanol extract at doses of 600 and 800 mg/kg (b.wt.) in open field test. A dose dependent decreased (p < 0.001) in crossing of cages and dipping head were found with extract receiving groups in cage crossing and head dipping test. P. glaucus, did not show any muscle relaxant effect caused significant (p < 0.001) increased in stay time. Moreover, caused significant (p < 0.001) increase in mobility and decrease in immobility time. The findings of this study revealed significant neuropharmacological potential of P. glaucus.