A New Anti-Cancer Drug Delivery System: Polymeric Ionic Liquid Functionalized Reduced Graphene Oxide
LATIN AMERICAN JOURNAL OF PHARMACY(2019)
Abstract
Graphene oxide (GO) has been one of the most proposed nanocarriers for drug delivery in the past decade. Here we synthesized a novel reduced graphene oxide (RGO) nanocomposite (RGO-PILs), functionalized by polymeric ionic liquids (PILs), which exhibited excellent loading capacity, favourable biocompatibility and good solubility as a nanocarrier for doxorubicin (DOX). The characters of RGO and RGO-PILs such as zeta potential, particle size, loading rate, entrapment efficiency and release profile were all investigated. The encapsulation efficiency of DOX for RGO-PILs was estimated to be around 71.9 +/- 1.9%. The release rate of DOX within 2160 min in pH 7.4 and pH 4.8 were 23 and 43%, respectively. No bursting effect was shown in the release profiles of RGO-PILs/DOX. As a novel nanocarrier, the RGO-PILs exhibited high drug loading and delivery capicity, favourable control-released property and pH sensitive releasing mechanism, which is desirable for therapeutic applications.
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Key words
doxorubicin,graphene oxide,nanocarrier,pH-sensitive,polymeric ionic liquids,RGO-PILs
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