Studies on the Synthesis of Benzene Sulfonamides, Evaluation of Their Antimicrobial Activities, and Molecular Docking

New series of sulfonamides were synthesized and investigated as antimicrobial agents. The structures of newly synthesized compounds were described by IR, H-1 and MS spectral data. Antibacterial and antifungal activities were evaluated with ciprofloxacin and itraconazole using disc diffusion method and minimum inhibitory concentration values were determined by 96-well plate assay method. Our studies showed that compounds 13-16 have promising antibacterial against the S. aureus having MIC 0.98 mu g/mL and IC50 ranged between 43-10 mu g/mL while 16 has promising antifungal activity. clogP was computed to describe the lipophilic character and it was found that the compounds possessing higher clogP have high activity against S. aureus. Molecular docking studies of reported compounds were also performed on S. aureus dihydropteroate synthase enzyme to identify the plausible binding modes and to explore the binding mechanism of these compounds.