Preparation and Characterization of Fenofibrate and Glycyrrhizic Acid Solid Dispersions by Co-Grinding

The solid dispersions of fenofibrate (FNB) and glycyrrhizic acid (GA) were prepared by cogrinding. The interaction of FNB with GA was investigated by X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscope and nuclear magnetic resonance spectroscopy. In addition, in vitro drug dissolution, stability and pharmacokinetic were also used to evaluate the solid dispersions. The results showed that FNB/GA solid dispersions were successfully prepared by co-grinding. The prepared solid dispersions had improved dissolution, stability and bioavailability of FNB, compared with pure drug without additives and physical mixings of FNB with GA.