A Heterometallic Coordination Polymer: Crystal Structure and Anti-Lung Cancer Activity

By employment of the ligand pyridine-2,5-dicarboxylic acid (2,5-H(2)pydc) containing both carboxylate and pyridine donor atoms as the organic linker, a heterometallic coordination polymer with the chemical formula of [LaCu(2.5-pydc)2(H2O)(4)]Cl-4H(2)O (1) has been successfully prepared under the hydrothermal conditions with the presence of NaOH as the pH modulator. Its anti-cancer activity was evaluated in vitro and the protentional mechanism was discussed at the same time. Firstly, the Cell Counting Kit-8 was performed to detect the inhibitory effect of complex 1 on the cancer cell viability. Next, the reverse transcription-polymerase chain reaction (RT-PCR) preformation was conducted to determine the relative expression of miR- 16-1 after complex 1 treatment. In addition to this, the western blotting assay was also finished to measure the Bcl-2 expression level after complex 1 treatment.