Development of an LC–MS/MS method for quantifying ASK120067, a novel mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) as well as its main metabolite in human plasma and its application in a pharmacokinetic study
Journal of Chromatography B(2021)
摘要
•ASK120067 is a third-generation EGFR-TKI for the treatment of NSCLC.•An LC-MS/MS method was developed to detect ASK120067 and its metabolite in plasma.•This method was fully validated from whole blood collection to plasma analysis.•This high-throughput method was rapid in analysis and simple in sample preparation.•This method was applied for a first-in-human clinical trial in Chinese patients.
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关键词
EGFR-TKI,ASK120067,CCB4580030,LC-MS/MS,Protein precipitation,Pharmacokinetics
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