T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells

Marco Lepore,Deborah A Lewinsohn,David M Lewinsohn

Molecular Immunology（2021）

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摘要

•MR1 can present multiple distinct ligands to T cells.•Diverse Human MR1 restricted T cells recognise distinct microbial or self/tumour antigens.•Individual MR1-restricted TCR display ligand discriminations.•Some MR1-restricted TCRs are cross-reactive toward multiple ligands.•Human MR1-restricted T cells are functionally heterogeneous.

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关键词

TCR,CDR,TRAV,TRBV,TNF-α,IFN−γ

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