Microextraction by packed sorbent optimized by statistical design of experiment as an approach to increase the sensitivity and selectivity of HPLC-UV determination of parabens in cosmetics

Journal of Pharmaceutical and Biomedical Analysis(2021)

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摘要
•Microextraction by packed sorbent (MEPS) was optimized by design of experiment (DOE).•The optimal conditions for the extraction of parabens from cosmetics are selected.•The analytical characteristics of the developed MEPS-HPLC-UV method were evaluated.•Analysis of real cosmetics including labeled “paraben-free” was performed.
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关键词
Microextraction by packed sorbent,Cosmetics,Parabens,High-performance liquid chromatography,Plackett–Burman design,Response surface methodology
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