Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water
JOURNAL OF ORGANIC CHEMISTRY(2021)
Abstract
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.
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Key words
ynamines,ynamides,synthesis,sulfonamide-based
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