Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman

Asheebo Rojas,Hilary S. McCarren,Jennifer Wang,Wenyi Wang,JuanMartin Abreu-Melon,Sarah Wang,John H. McDonough,Raymond Dingledine

NeuroToxicology（2021）

引用 8|浏览12

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摘要

•Electrographic status epilepticus is similar for rats administered soman and DFP.•Neuroinflammation and gliosis is lower after soman-induced SE compared to DFP.•Weight change, BBB leakiness and cell death is similar for soman and DFP-induced SE.•The overall SE-induced pathology was similar in rats administered soman and DFP.

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关键词

SE,GFAP,IBA1,CA1,CA3,CT,Con,COX-2,cFos,DFP,OP,IP,SC,FJB,qRT-PCR,IL-1β,TNFα,CXCL10,CCL2,CCL3,CCL4,IL-6,GAPDH,HPRT1,gp91phox (NOX2),IHC,DFP-SE,soman-SE

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