Measurement and correlation of the solubility of antipyrine in ten pure and water + ethanol mixed solvents at temperature from (288.15 to 328.15) K

The aim of this experiment is to obtain new antipyrine solubility data and the correlation equation parameters and thermodynamic parameters of the dissolution process. The solubility of antipyrine was experimentally measured in ten mono-solvents (methanol, ethanol, acetone, n-propanol, isopropanol, methyl acetate, n-butanol, isobutanol, ethyl acetate, water) and binary mixed solvents (ethanol–water) at 288.15 to 328.15 K using a gravimetric method under atmospheric pressure. In addition, the experimental solubility in the mono- and mixed solvents was correlated using the λh equation, modified Apelblat equation, nonrandom two-liquid equation, Wilson equation, and van't Hoff equation. Good agreement was found between the experimental values and correlation values calculated by all the selected equations. The thermodynamic parameters, Gibbs energy (∆G°sol), molar enthalpy of dissolution (∆H°sol), and molar entropy of dissolution (∆S°sol) were also calculated. These experimental results are crucial for optimization of the antipyrine crystallization process.