Catalytic Polymersomes To Produce Strong And Long-Lasting Bioluminescence
NANOSCALE(2021)
Abstract
Here, we introduce an artificial bioluminescent nanocompartment based on the encapsulation of light-producing enzymes, luciferases, inside polymersomes. We exploit nanocompartmentalization to enhance luciferase stability in a cellular environment but also to positively modulate enzyme kinetics to achieve a long-lasting glow type signal. These features pave the way for expanding bioluminescence to nanotechnology-based applications.
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Key words
bioluminescence,catalytic polymersomes,long-lasting
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