Development and course of diabetes according to genetic factors and diabetes treatment among patients with nonalcoholic fatty liver disease

•Half of patients with nonalcoholic fatty liver disease (NAFLD) also had diabetes•Body weight reduction tended to be greater after 6 mo of sodium glucose cotransporter 2 inhibitor treatment (P = .050) and significantly higher in patients with versus without the voltage-gated potassium channel KQT-like subfamily member 1 CC genotype (P < .05)•Hemoglobin A1c reduction level was significantly lower in patients with versus without the patatin-like phospholipase 3 GG SNP (P < .05)•New-onset diabetes occurred in 44 patients (10-y incidence rate: 17.9%) and was particularly prevalent in obese patients (P = .046) and those with the voltage-gated potassium channel KQT-like subfamily member CC genotype (P < .01)