Modulation of gene expression by green tea in relation to its beneficial health effects

Green tea has been known to exert various beneficial health effects. In the present study, we examined its effects on gene expression using RT-PCR, real-time PCR, and DNA microarrays. Epigallocatechin gallate, a major green tea polyphenol, suppressed gene expression of matrix metalloproteinases in HT-1080 cells and hepatic gluconeogenic enzymes in mice. Oral administration of green tea attenuated the up-regulation of gene expression of inflammatory cytokines and collagen in rat galactosamine-injured livers. These data provide the basis of the protective effects of green tea against cancer metastasis, diabetes, and hepatitis.