Efficacy of E2 glycoprotein fused to porcine novel chimeric subunit vaccine to prevent classical swine fever transmission in pregnant sows (vol 205, pg 110, 2017)

Sara Munoz-Gonzalez,Yusmel Sordo,Marta Perez-Simo,Marisela Suarez,Albert Canturri,Maria Pilar Rodriguez,Maria Teresa Frias-Lepoureau,Mariano Domingo,Mario Pablo Estrada,Llilianne Ganges

Veterinary Microbiology（2018）

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摘要

•The E2-CD154 subunit vaccine elicited a potent neutralising antibody response in pregnant sows.•This vaccine conferred protection against CSFV vertical transmission after two immunizations.•This vaccine may has DIVA potential being a safe alternative for endemic countries.

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关键词

CSFV,CD40-ligand,CD154,E2 glycoprotein,Chimeric subunit vaccine,DIVA,Immunization,Neutralizing antibody response,Virological protection,Vertical transmission

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