PATHOGENETIC MECHANISMS OF STRESS-INDUCED EXPERIMENTAL INFLUENZA A AGGRAVATION AND ITS PREVENTION

It was stated that in stress-induced aggravation of infection realized in transformation of nonlethal patterns of infection into a lethal one there occurred a manifest dysfunction of hypothalamohypophyseoneurosecretory performance (HHNS) featured by a 2-fold decrease in the blood vasopressin and an essential elevation of the hypothalamic one. The phenomenon is being suggestive of a possible blockage in the hormonal discharge into circulation and the limitation of its participation in the development of defensive and compensatory reactions. Identical HHNS dysfunction was noted in the lethal pattern of the infection. The authors formulated the concept of the main pathogenetic points underlying the damage of vegetative regulation centres. Mechanisms of viral and tissue metabolitic damage of CNS were revealed. The authors substantiated the advisability and prospectivity of antioxidants as applied to the prevention of severe course of influenza and its complications in extremely aggravated patterns.