Immuno-hippo: Research progress of the hippo pathway in autoimmune disease

Paipai Guo,Zhen Wang,Zhengwei Zhou,Yu Tai,Aijun Zhang,Wei Wei,Qingtong Wang

Immunology Letters（2021）

引用 6|浏览2

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摘要

•Hippo-YAP regulates innate immune response and adaptive immune response.•A variety of AID has found abnormal activation of the Hippo pathway.•The lack of MST1 can cause immunodeficiency in the adaptive immune response.•The Hippo pathway may become a promising treatment strategy for AID.

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关键词

YAP,Sav1,AID,NF-κB,JAK-STAT,TNF-α,TNF-RSC,LUBAC,VNN1,TRAF2,LPS,IL-6,IκB,HDAC7,IFN-α,ISGs,VEGF,EGF,LPA,PI3K,MAPK,JNK,HIF-1α,IRF3,TBK1,RA,PID,DCs,CCL19,UC,PV,SLE,SS,SSc,IBDs,CD,DSS,EAE,T1D,T2D,PDX1,PVA,Dsg3,SMG,TGF-β,AP-1

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