Efficient Unified Synthesis Of Diverse Bridged Polycyclic Scaffolds Using A Complexity-Generating 'Stitching' Annulation Approach

Regioselective and stereospecific directed C-H arylation of simple amine substrates, and cyclisation, delivered 30 diverse, three-dimensional scaffolds. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring.