Persistent expression of microRNA-125a targets is required to induce murine hematopoietic stem cell repopulating activity

D G Luinenburg, A B Dinitzen,A Flohr Svendsen, R Cengiz,A Ausema,E Weersing,L Bystrykh,G de Haan

Experimental Hematology（2021）

引用 3|浏览19

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摘要

•Continuous expression of miR-125a is required to induce self-renewal of HSCs.•Cre-LoxP excision is a reliable tool for reversal of microRNA expression in HSCs.•Novel miR-125a-associated genes that affect HSC function are identified.

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关键词

murine hematopoietic stem cell,stem cell

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