Single-cell profiles of human bone marrow-derived mesenchymal stromal cells after IFN-γ and TNF-α licensing

Gene（2021）

引用 11|浏览6

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摘要

•IFN-γ and TNF-α licensing didn’t influence the cell cycle of MSCs.•IFN-γ and TNF-α licensing increased chondrogenesis MSC populations and decreased osteogenesis MSC populations.•IFN-γ and TNF-α licensing changed MSCs into anti-inflammatory populations uniformly.

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关键词

MSC,CXCR4,ITGA6,MCAM,OCT4,NANOG,DPPA3,SALL4,BMI1,PPARG,CIDEC,ADIPOQ,CD36,FABP4,AOC3,RUNX2,SP7,ALPL,BGLAP,COL1A1,OGN,SOX5,SOX6,COL10A1,COL11A1,ACAN,COMP,CCL2,CCL5,CCL8,CXCL9,CXCL10,CXCL11,IDO1,PTGS2,IL6,TGFB1,HMOX1,LGALS1,CD274,ICAM1,VCAM1,FAS,HLA-DRA,HLA-DRB1

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