HIGH-INTENSITY THz PULSES APPLICATION TO PROTEIN CONFORMATIONAL CHANGES

A new method for conformational changes of enzymes under very intense and short electric field is proposed. The molecular dynamics of linoleate 9/13-lipoxygenase from Pseudomonas aeruginosa was simulated for frequencies ranging from 1 to 15 THz under electric field of 10(7) V/m with pulse length of 2 ps. Multiple intense THz field is generated by combining two-color plasma filamentation with a method for splitting and delaying short laser pulses. Large conformational changes of protein structure are predicted by using mu J THz pulse energy with 15 THz bandwidth.