COLLAGEN HYDROLYSATE-BASED INGESTIBLE BIOPRODUCTS FOR THE TREATMENT OF GASTRIC DISORDERS

Gastric ulcer disease is a common problem of the gastro-intestinal tract with its increasing incidence and prevalence attributed to the loss of balance between aggressive and protective factors. The purpose of this study was to obtain and characterize biomaterials for the regeneration of the soft tissue of the digestive system. Powders with different concentrations of collagen hydrolysate, zeolite and propolis were obtained by lyophilization. The type I collagen hydrolysate was obtained by acidic hydrolysis. A stable DPPH radical was used for determination of the free radical scavenging activity of the propolis. The morphology (Scanning Electron Microscopy - SEM), the spectral characteristics (Fourier Transform Infrared Spectroscopy - FT-IR, X ray diffraction - XRD), the goniometry (contact angle), in vitro assessment to simulated gastric acid and the biocompatibility (XTT assay) of the designed powders were studied. The collagen hydrolysate, zeolite and propolis biomaterials exhibited characteristics that make them potential candidates for use in the treatment of gastric ulcer.