Synthesis, Physico-Chemical and Toxicological Characterization of New Complexes of Lanthanides (III) with Ampiroxicam and Lornoxicam

The metallic complexes with pharmacological activity are considered, nowadays, an important research field, in the bioinorganic chemistry. They owe this interest because of the synergy between the ligands effects and those of the metals, which leads to the increase of the therapeutic activity for the new compound. This paper describes the synthesis, physico - chemical and toxicological characterization of new Ln(III) with oxicam ligands namely ampiroxicam and lornoxicam, potential active substances of new antitumoral drugs. The structures and formula proposed for these coordination compounds were established on the basis of Quantitative Structure - Activity Relationships /Computer Assisted Drug Design (QSAR/CADD) studies and correlation with the elemental chemical analysis and other physical - chemical studies (UV-Vis, ICP-MS, IR spectrometry). Cytotoxicity of lanthanide complexes was estimated comparatively to oxicam ligands.