Synthesis and Myelostimulatory Activity of β-Cyclodextrin Complexes of 3,7-Diazabicyclo[3.3.1]Nonan-9-One Derivatives
PHARMACEUTICAL CHEMISTRY JOURNAL(2020)
摘要
Simultaneous Mannich condensation of 1-(3-methoxypropyl)piperidone-4 with paraformaldehyde and 1-(2-pyridinoethyl)amine yielded 3-(3methoxypropyl)-7-[2-(pyridin-2-yl)ethyl]-3,7-diazabicyclo[3.3.1]nonan-9-one, which was reduced to the corresponding bicyclic nonane under Huang—Minlon reaction conditions. The reaction of 3,7-diazabicyclo[3.3.1]nonan-9-one with hydroxylamine hydrochloride led to the corresponding oxime, subsequent acylation of which synthesized its O -benzoyloxime. Replacement of the morpholine or piperazine ring in 3-(3-ethoxy- or isopropoxypropyl)-7-[2-( N -morpholino- or N -piperazino) ethyl]-3,7-diazabicyclo[3.3.1]nonane by pyridine led to a loss of activity. However, 3-(3-methoxy- and isopropoxypropyl)-7-[2-(pyridin-2-yl- and N -piperazino)ethyl]-3,7-diazabicyclo[3.3.1]nonan-9-one O -benzoyloximes were myelostimulators although they differed in that the β-cyclodextrin complex of 3-(3-methoxypropyl)-7-[2-(pyridin-2-yl)ethyl]-3,7-diazabicyclo[3.3.1]nonan-9-one O -benzoyloxime stimulated both erythro- and leukopoiesis while its N -piperazine analog stimulated only leukopoiesis.
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关键词
3,7-diazabicyclo[3.3.1]nonan-9-one and its derivatives,β-cyclodextrin complex,myelostimulatory activity,toxicity
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