The association of polymorphisms of vascular reaction genes with blood pressure levels in pregnant women of Belgorod region

This paper presents the results of studies of the association of genetic polymorphisms of K198N endothelin 1, G460W alpha-adducin with blood pressure indicators in women during early pregnancy. The study was conducted on a sample of 591 women. Blood pressure was analyzed both prior to pregnancy and during pregnancy on week 37-40. Genotyping of the polymorphisms of endothelin-1 (K198N ET-1) and alpha-adducin (G460W ADD1) was carried out by polymerase chain reaction (PCR). It was determined that the genetic variants 198KK and 198KN ET-1, 460WW ADD1 are associated with the more pronounced blood pressure dynamics in women at fertilization and its high level at the end of pregnancy.