Clinical and Genetic Research of Chronic Glomerulonephritis

The paper presents data on interaction of candidate genes (S311C PON2, (-6)A/G AGT, (-1166)A/C AGTR1, (-592)C/A IL-10, VNTR IL-1Ra, T113M IL-9, K198N EDN1, (+46) G/A ADRB2, G/A GNB3 (rs.2301339)) with oligogenic and continuous characters of chronic glomerulonephritis. The associations of polymorphisms (-6) A/G AGT and VNTR IL-1Ra with acute nephritic and hematuric syndromes at onset of the disease (OR = 2.62 and OR = 2.04, respectively) were defined. It was found that the molecular genetic markers 311SS PON2 and (+46) AA ADRB2 were connected with increased creatinine and haematuria in patients with chronic glomerulonephritis (p = 0.05 and p = 0.03, respectively).