Clinicopathological Changes in Sera of Broiler Chicken Given Antibacterial and Or Prebiotics

Aim of this study to investigate effect of colistin and or tylosin in presence or absence of prebiotics on liver and kidney function. A total number of 320, 1- day old broiler chicks were divided into 8 equal groups,40 chicks in each. Tylosin and colistin were used 3 times at the 1st 5, 2nd from days 10-15 and 3rd from days 20-25 of age while lysozyme was used start from day 5 till day 25 of age. Blood samples collected from each group for liver and kidney function test together with liver and kidney tissue samples for histopathological examination at 15 and 30 days of life. Results of liver function The recorded liver function test at the 30th day of life the lowest serum Glutamate pyruvate transaminase (GPT) was 2.22 +/- 0.67 in lysozyme, followed by 2.50 +/- 0.84, 2.67 +/- 0.82 and 3.33 +/- 0.82 in groups given lysosyme with colistin, tylosin and Tylosin -colistin; respectively. Groups given drugs only tylosin, colistin, tylosin[ and Tylosin - colistin showed 3.95 +/- 0.88, 4.00 +/- 2.28 and 4.10 +/- 1.27; respectively. Nearly Same battern was seen in both of serum albumin and creatinine levels. Results of histopathology proved that groups given lyszyme showed milder liver and kidney lesions than those given drugs only. Birds given combined drugs show more sever lesions than those given separate drug. Tylosin exert more adverse effective on liver, while colistin showed to be more adverse effect on kidney. Administration of lysosime improve the adverse effect of drug on tested tissue sections. It could be concluded that birds given combined drugs show more sever lesions than those given separate drug. Tylosin was more effective on liver, while colistin showed to be more effect on kidney. Administration of lysozyme improve the adverse effect of drug on tested tissue sections. Therefore, we advice to administer the used drugs in the recommended dose with prebiotic to get better results.