Factors affecting lymph node yield in squamous cell carcinoma of mandibular Gingivo-Buccal sulcus.

Lymph node yield (LNY) is a valid marker of prognosis in oral cancer. Precise estimation of LNY in Indian patients with T3/T4 gingivobuccal sulcus squamous cell carcinoma (GBS-SCC) has not been well documented. Hence, the primary. objective. of the study was to determine LNY in patients with T3/T4 SCC of mandibular GBS, and the secondary objective was to study the association of LNY with clinicopathological factors such as tumor thickness, histological differentiation, number of positive nodes, and. extracapsular spread.(ECS). Study patients comprised biopsy proven T3/T4 SCC of mandibular. GBS that underwent unilateral surgery (composite or bite composite resection,with level I to level V-neck dissection and pectoralis major flap reconstruction) at sree balaji dental college and hospital,chennai in between year 2014 to 2016. Grossing of surgical specimens was done as per the guidelines established by the Royal College of Pathologists (December 2009). The surgical specimens of 12 patients yielded 320 lymph nodes with the mean LNY of 21.00 +/- 5.00. Higher mean LNY of over 21 was significantly associated with ECS, number of positive nodes, delay in surgery over 15 days, skin involvement by the tumor, and presence of oral potentially malignant disorders. With the single surgeon, pathologist and same surgical procedure, the mean LNY in Indian patients with T3/T4 SCC of mandibular GBS is 21.00 +/- 5.00. Although clinicopathological factors affect the estimation of LNY, further studies are needed to validate the findings of this study.