Development and Evaluation of Oro dispersible tablets of Rosuvastatin calcium By beta-Cyclodextrin inclusion complexes and using different Superdisintegrants

Rosuvastatin Calcium exhibit unsatisfactory dissolution profiles and, consequently, problems of absorption and poor bioavailability. Rosuvastatin Calcium (RST), a poorly water-soluble 3-hydroxy3-methyl glutaryl CoA (HMG-CoA) Reductase inhibitor through inclusion complexation with beta-cyclodextrin (beta-CD). The aim of this work was to develop Rosuvastatin Calcium Orodispersible tablets by exploiting the solubilizing effect of beta-cyclodextrin (beta-CD). Drug-CD complex systems, prepared by different techniques, Precipitation method, Kneading method, and Co-evaporation method, they were characterized by Fourier transform infrared (FT-IR) spectroscopy. The inclusion complex containing RST: beta-CD (1:1) was formulated into tablets using superdisintegrants like sodium starch glycolate, Crosspovidone and Crosscarmellose. Tablets containing RST- beta-CD inclusion complex were prepared by direct compression and evaluated for various post compression parameters like hardness, friability, weight variation, thickness, drug content and in-vitro dissolution. A significant improvement of the drug dissolution profile was achieved from tablets containing drug-CD systems Kneading method products showed the best dissolution profiles, reaching more than 97.05% drug release at the end of 30 min.