Effect of antileukotriene (zileuton) in patients with bronchial asthma (emphasized reactors, moderate reactors, and non-reactors)

Effect of antileukotriene - Zileuton in patients with bronchial asthma with increased, and moderate reactivity or non-reacting. Parameters of the lung function are determined with Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was calculated. Zileuton, tabl. 600 mg was used in the research. 2 days after administration of the antileukotriene medicine - Zileuton (4 x 1 tabl.) at home, on the third day to patients measured initial values by administering orallyone more tablet of Zileuton in a dose of 600 mg, and again measured Raw and ITGV after 60, 90 and 120 min. and calculated was SRaw. In emphasized reactors, we have significant decrease of the airways bronchomotor tonus (p < 0.01). In moderate reactors, there was also a significant decrease of the specific resistance of airways (p < 0.05). There were no significant changes of the airways bronchomotor tonus in non-reactors (p > 0.1). Effect of the corticosteroids (Berotec) in the control group is also effective in removal of the increased bronchomotor tonus, by causing significant decrease of the resistance (Raw), respectively of the specific resistance (SRaw), (p < 0.01). This suggests that the bronchodilation effect of Zileuton at patients with emphasized reactivity is more powerful than at the patients with moderate reactivity and non- reactors, which means that antileukotriene - Zileuton interferes the early stage of the release of chemical mediators (prostaglandins PgD(2), SRS, and leukotriene LTC4, LTD4, LTE4 and Cytokinin's etc.) as powerful broncho constriction substances. Effect of antileukotriene (Zileuton) is not immediate after oral administration, but strong effect of Zileuton seen only after two days of cys-LT's inhibition, and inhibition of leukotriene B4 (LTB4) and A4 (LTA4) at patients with increased reactivity.