A review on liposomal drug delivery system

R. Muralikrishnan, R. Selvamuthukumar, A. Mohankumar, K. Praveen,M. Swamivelmanickam, S. Sivakrishnan

RESEARCH JOURNAL OF BIOTECHNOLOGY(2020)

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摘要
Liposomes are microparticulate created from lipoidal vesicles. It absolutely was used as drug carriers in enhancing the delivery of therapeutic agents. Liposomes, that are perishable and necessary nontoxic vesicles, will encapsulate each deliquescent and lipotropic medicine and yet maintain them from the external condition that end up in degradation. Several liposomes based mostly drug strategies are within the trial, and that they are approved for clinical use. Liposome may be target on the tissues, cells and animate thing compartments with or blankly of target recognition on liposome membrane. The grouping of liposome provides an opportunity to reinforce the therapeutic index of assorted dynamic medicine by ever changing their pharmacokinetic and pharmacodynamics parameters. The success of liposome as drug carriers is seen within the range of liposome formulation which are commercially there in the market. During this review, we tend to discuss the mechanism of liposome formation, methods of preparation, classification of the liposome, evaluation of liposome, their applications and marketed products.
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关键词
Liposomes,Pharmacokinetics,Intracellular Compartments,Drug Delivery
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