PAKISTANI ANTI-MASTITIS MEDICINAL PLANTS AND THEIR SCIENTIFIC VALIDATION AGAINST MULTIDRUG RESISTANCE MASTINOGEN STAPHYLOCOCCUS AUREUS

Mastitis is an infectious disease of livestock affecting agricultural economy especially in developing countries. Present review was designed to gather literature about the traditional uses of Pakistani anti-mastitis plants and their In vitro background against a common multidrug resistant mastitis causing bacteria Staphylococcus aureus. Different online search engines were used use to collect data such as Web of Science, Scopus, Google Scholar and Pub Med.Traditional healers of Pakistan used 38 plants for the treatment of mastitis in buffaloes and cows. Zingiberaceae, Asteraceae, Rutaceae and Solanaceae (3 plants each) were the most preferred plant families while the roots, fruits and seeds were the most commonly used parts for the treatment of mastitis in Pakistan. Thirteen plants were reported to be evaluated for their antibacterial activities. Different extracts had shown good activities against S. aureus, however, ethanolic, aqueous and methanolic extracts shown greater inhibition zone (10-25mm). Variety of phytochemical classes was identified from in-vitro tested plants such as saponins, glycosides, alkaloids, carbohydrates flavonoids and terpenoids. Literature review showed that S. aureus is resistant (60-100%) to commonly used antibiotics against mastitis. In Pakistan large number of plants are being used against mastitis but most of the regions are yet to explore. Moreover, many reported plants were found to be active against S. aureus while large number of plants is still unexplored. There is a dire need to expedite detailed ethnopharmacological studies on unexplored anti-mastitis plants for the replacement of current drugs with new plant based drugs.