Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model

Anqi Wang,Changhao Xiao,Jianxian Zheng, Chuansong Ye,Zhen Dai,Qinghai Wu,Jinguang Liu,Padraig Strappe,Zhongkai Zhou

Journal of Functional Foods（2020）

引用 16|浏览6

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摘要

•GLT improved hepatocyte cellular and hippocampal neurons morphology of aged rats.•Expression of FOXO4 and SIRT1 genes was up-regulated by GLT intervention.•PI3K/AKT/mTOR pathway activation was associated with reversed cognitive impairment.•Current results highlight potent roles of GLT on improving the aging status.

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关键词

Triterpenoids,Aging,Oxidative stress,Inflammation,PI3K/AKT/mTOR pathway

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